1. Depressed mood most of the day, nearly everyday, as indicated either by subjective account or observation by others.

2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly everyday.

3. Significant weight lossor weight gain when not dieting (i.e more than 5% of body weight in a month), or decrease or increase in apppetite nearly everyday.

4. Insomnia or Hypersomnia nearly everyday.

5. Psychomotor agitation  or retardation n.e.

6. Fatigue or loss of energy n.e.

7.Feeling of worthlessness or excessive or inappropriate guilty n.e.

8. Diminished ability to think or concentrate, or indicesiveness n.e.

9. Recurrent thoughts of death, suicide (attempt, plan, idea).